Scientific Publications

Project Publications

Paraplegia prevention in aortic aneurysm repair by thoracoabdominal staging with ‘minimally invasive staged segmental artery coil embolisation’ (MIS²ACE): trial protocol for a randomised controlled multicentre trial 

BMJ Open 2019; 9:e025488

Publication of the clinical trial protocol which is the basis of the PAPAartis project

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Near real-time bedside detection of spinal cord ischaemia during aortic repair by microdialysis of the cerebrospinal fluid

Eur J Cardiothorac Surg. 2020 Sep 1;58(3):629-637.

Publication showing it is possible to detect three markers of SCI in experimental models and in a small number of patients using microdialysis. This supports a subproject of PAPAartis aiming to identify clinically relevant markers of SCI in CSF to develop a bed-side test.

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“There is nothing better than participating in this study”: Living the PAPAartis cardiovascular randomised controlled trial

Contemp Clin Trials Commun 2022 Sep 3; 29:100987. 

Publication of the first results of the qualitative analysis of patient experience and decision making during their participation in the PAPAartis clinical trial.

Background Publications

Setting the stage: Thoracoabdominal aortic aneurysm repair in 2 acts

J Thorac Cardiovasc Surg 2015 Apr;149(4):1079-80.

Editorial comment on the paper below.  The editors highlight the need for staged repairs of aortic aneurysms to be at the forefront of the minds of those carrying out aneurysm repairs and describe the strategy to be tested in PAPAartis as 'exposing a new frontier in managing and preventing spinal cord injury'. 

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First-in-man endovascular preconditioning of the paraspinal collateral network by segmental artery coil embolization to prevent ischemic spinal cord injury

J Thorac Cardiovasc Surg. 2015 Apr;149(4):1074-9.

Publication of the results of the first-in-man experience using minimally invasive, selective segmental artery endovascular coil embolization before aortic aneurysm repair. This showed the procedure is clinically feasible and may eventually eliminate ischaemic spinal cord injury. These results inspired the concept of the PAPAartis project  - to test this strategy in a randomised controlled multicentre clinical trial. 

Other Publications